SIRT6 Study
Targeted modulation of SIRT6 pathways to slow aspects of biological ageing
Study Overview
The SIRT6 study explores how modulating SIRT6 — a key enzyme that regulates DNA repair, metabolic balance, and longevity — can influence biological ageing and improve overall health in adults.
Participants attend four visits over six months (Screening, Month 0, Month 3, Month 6). Each visit includes detailed assessments of biological age, metabolic health, body composition, cognition, skin and vascular condition, and quality of life.
The aim is to determine whether targeted activation of SIRT6 pathways can meaningfully reduce biological age and enhance healthspan-related markers.
The study is conducted at the Academy for Healthy Longevity, National University of Singapore (NUS) under the supervision of Prof. Andrea B. Maier. It is designed to produce clinical-grade, reproducible evidence to guide future precision-longevity interventions.
Join our study
Inclusion highlights
Adults aged 50 – 80 years, generally healthy
Able to commit to all study visits
No chronic or unstable medical conditions affecting safety or metabolism
Duration
~6 months total participation.
Reimbursement
Participants receive 30SGD reimbursement per visit and free health screening
Key team members
Prof. Andrea B. Maier, MD PhD FRACP, Jozo Grgic, Ajla Hodzic Kuerec, Weilan Wang, Lihuan Guan, Dingding Zhang, Mazzarine Dotou
Chew Yi Ern, Anees Begam, Sharon Nadiyah, Atikah Dahiyah, Chong Hui Min, Renee Chng, Natasha To Anan, Maiyunis Yusoff, Saiful Anwar, Jiaqu Wang, Chen Tong